Vagus nerve stimulation in chronic treatment-resistant depression
نویسندگان
چکیده
منابع مشابه
Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study.
BACKGROUND The need for effective, long-term treatment for recurrent or chronic, treatment-resistant depression is well established. METHODS This naturalistic follow-up describes outpatients with nonpsychotic major depressive (n = 185) or bipolar (I or II) disorder, depressed phase (n = 20) who initially received 10 weeks of active (n = 110) or sham vagus nerve stimulation (VNS) (n = 95). The...
متن کاملA patient-level meta-analysis of studies evaluating vagus nerve stimulation therapy for treatment-resistant depression
OBJECTIVE To compare response and remission rates in depressed patients with chronic treatment-resistant depression (TRD) treated with vagus nerve stimulation (VNS) Therapy(®) plus treatment as usual (VNS + TAU) or TAU alone in a meta-analysis using Bayesian hierarchical models. DATA SOURCES AND STUDY SELECTION Six outpatient, multicenter, clinical trials that have evaluated VNS + TAU or TAU ...
متن کاملVagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial.
BACKGROUND Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy. METHODS This 10-week, acute, randomized, controlled, masked trial compared adjunctive VNS with sham treatment in 235 outpatients with nonpsychotic major depr...
متن کاملVagus nerve stimulation for treatment-resistant depression: behavioral and neural effects on encoding negative material.
OBJECTIVES Vagus nerve stimulation (VNS) can improve depression. Cognitive models of depression highlight an over-representation of negative thoughts and memories, with depressed individuals showing memory facilitation for negative material. We hypothesized that the antidepressant action of VNS may emerge through corrective influences on 'negativity bias' in memory. We therefore examined the im...
متن کاملVagus nerve stimulation therapy randomized to different amounts of electrical charge for treatment-resistant depression: acute and chronic effects.
BACKGROUND Major depressive disorder is a prevalent, disabling, and often chronic or recurrent psychiatric condition. About 35% of patients fail to respond to conventional treatment approaches and are considered to have treatment-resistant depression (TRD). OBJECTIVE We compared the safety and effectiveness of different stimulation levels of adjunctive vagus nerve stimulation (VNS) therapy fo...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 2006
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.bp.105.018689